Zepbound®

Achieve Sustainable Weight Loss

At Genesis Lifestyle Medicine, we proudly prescribe Zepbound^® (tirzepatide) in person as part of our comprehensive medical weight loss programs. This breakthrough medication helps patients achieve sustainable weight loss by targeting key metabolic pathways. Our expert providers tailor your weight-loss program to support long-term success and overall wellness from the inside out.

Lose Up to 20% of Your Weight

Zepbound is an FDA-approved prescription medication that supports weight loss in adults with obesity or adults with overweight in the presence of at least one weight-related comorbid condition. It mimics natural gut hormones to reduce appetite, increase feelings of fullness, and regulate blood sugar levels. When combined with a healthy diet and increased physical activity, Zepbound can help patients lose up to 20% of their body weight.*

At Genesis Lifestyle Medicine, we provide in-person evaluations to ensure Zepbound is the right fit for you and offer personalized care to help you achieve and maintain your desired weight.

Benefits of Zepbound:

Reduce appetite and control cravings
Support significant, sustainable weight loss
Mimic natural hormones for improved metabolism
Enhance feelings of fullness after meals
Regulate blood sugar and insulin levels
Lower risk factors for heart disease and diabetes
FDA approved and backed by clinical trials
Prescribed in person by experienced medical providers
Administered as a convenient once-weekly injection

Potential Side Effects:

Common side effects include nausea, diarrhea, vomiting, constipation, stomach pain, indigestion, injection site reactions, sleepiness, allergic reactions, gas, hair loss, and heartburn. Do not use Zepbound if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). For complete safety information visit https://uspl.lilly.com/zepbound/zepbound.html.

How Does Zepbound Promote Weight Loss?

Zepbound works by mimicking hormones naturally produced in the gut that help regulate appetite and blood sugar. Its active ingredient activates two key hormone receptors—GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide). These hormones send signals to the brain that help reduce hunger, slow down digestion, and increase feelings of fullness after eating. This means you feel satisfied with smaller portions and are less likely to overeat, which helps facilitate weight loss.

In addition to curbing the appetite, it also helps regulate blood sugar levels and improve insulin sensitivity, which can be helpful for people with insulin resistance or prediabetes. By targeting multiple pathways involved in weight gain and metabolism, Zepbound creates a powerful effect that supports steady, sustainable weight loss.

Your Zepbound Weight Loss Experience

During your in-person consultation at Genesis Lifestyle Medicine, we evaluate your health history, weight loss goals, and lab work to determine if Zepbound is right for you.

If prescribed, you’ll receive clear instructions on how to self-inject Zepbound using a simple, prefilled pen. Injections are done once a week, typically in the abdomen or thigh. Dosage starts low and gradually increases based on your body’s response, ensuring maximum effectiveness with minimal side effects—all under the guidance of our experienced medical team.

Insurance Coverage for Zepbound

Coverage for Zepbound varies by insurance plan. Some commercial insurers may cover the medication, often requiring prior authorization. Medicare may also cover Zepbound for specific health conditions. We can help you understand your coverage options.

Schedule A Consultation

You May Be a Candidate for Zepbound If:

You have a BMI of 30 or higher (obesity)
You have a BMI of 27 or higher with weight-related conditions like type 2 diabetes
You struggle with chronic weight gain or difficulty losing weight through diet and exercise
You are looking for a non-surgical weight loss option
You are committed to making long-term lifestyle changes
You do not have a personal or family history of medullary thyroid cancer

How Much Weight Can You Lose With Zepbound?

Clinical trials have demonstrated that Zepbound can lead to significant weight loss when combined with a reduced-calorie diet and increased physical activity.

Over a 72-week period, participants without diabetes experienced average weight loss of approximately 15% (34 lbs) on a 5 mg dose, 19.5% (44 lbs) on a 10 mg dose, and 20.9% (48 lbs) on a 15 mg dose. In comparison, the placebo group saw an average weight loss of 3.1% (7 lbs).* However, individual results may vary, and it's essential to discuss with your healthcare provider to determine if Zepbound is appropriate for your weight loss goals.

Beautiful thin woman outside after EMSCULPT NEO in Indianapolis, IN

Zepbound FAQs

How quickly will I start losing weight with Zepbound?

Most patients begin to notice weight loss within the first few weeks, especially when Zepbound is combined with a healthy diet and regular exercise. Significant results often appear after 8-12 weeks of consistent use.

Is Zepbound safe?

Zepbound is FDA-approved and has been shown to be safe and effective in clinical trials. However, like other GLP-1 medications, it may cause side effects the most common of which include nausea, diarrhea, vomiting, constipation, stomach pain, indigestion, injection site reactions, fatigue, allergic reactions, gas, hair loss and heartburn. Zepbound may cause serious side effects, including possible thyroid tumors, including cancer. Do not use Zepbound if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). For complete safety information visit https://uspl.lilly.com/zepbound/zepbound.html. Our team will monitor you closely to manage any issues. Be sure to talk to your healthcare provider if you have any side effect that bothers you or that does not go away.

How often do I take Zepbound?

Zepbound is injected once a week using a prefilled, easy-to-use pen. You’ll rotate injection sites between the abdomen, thigh, and upper arm.

What happens if I miss a dose?

If you miss a dose, take it as soon as possible, within four days of the missed dose. If more than four days (96 hours) have passed, skip the dose and take your next injection on the regular schedule. Do not take 2 doses of Zepbound within 3 days (72 hours) of each other.

Contact Us for Your Zepbound Prescription

Genesis Lifestyle Medicine offers in-person Zepbound prescriptions as part of our personalized medical weight loss programs. Our experienced providers will guide you through every step—from initial evaluation to ongoing support—to help you achieve real, lasting results. We focus on whole-body wellness and tailor every plan to your unique needs. Schedule your consultation today and discover if Zepbound is right for you.

*Individual results vary. In a 72-week Zepbound (tirzepatide) study of adults without diabetes, average weight loss was 15.0% (34 lbs.) for 5 mg, 19.5% (44 lbs) for 10 mg, 20.9% (48 lbs.) for 15 mg, and 3.1% (7 lbs.) for placebo. In a 72-week Zepbound (tirzepatide) study of adults with diabetes, average weight loss was 12.8% (28 lbs.) for 10 mg, 14.7% (33 lbs.) for 15 mg, and 3.2% (7 lbs.) for placebo.

Jastreboff AM, Aronne LJ, Ahmad NN, Wharton S, Connery L, Alves B, Kiyosue A, Zhang S, Liu B, Bunck MC, Stefanski A; SURMOUNT-1 Investigators. Tirzepatide Once Weekly for the Treatment of Obesity. N Engl J Med. 2022 Jul 21;387(3):205-216. doi: 10.1056/NEJMoa2206038. Epub 2022 Jun 4. https://pubmed.ncbi.nlm.nih.gov/35658024

The information provided on this website is not a substitute for professional medical advice. Always consult with a qualified healthcare provider for any questions about your health or treatment.

Zepbound^® is a registered trademark of Eli Lilly and Company. This website is not affiliated with, endorsed by, or sponsored by Eli Lilly and Company. All trademarks and brand names are property of their respective owners. Use of these names, logos, and brands does not imply endorsement Genesis Lifestyle Medicine. Information about Zepbound is sourced from publicly available materials and is intended for educational and informational purposes only. All rights to such content belong to the respective company.