Losing weight is often an ongoing struggle, and no matter how much you try, it can feel like nothing works. You may have tried various diet plans, exercise routines, and even weight loss supplements, but the results seem disappointing. You might even feel stuck, frustrated, and unsure of what path to take next. It can be challenging to manage your weight and meet your personal goals, especially when traditional methods aren't effective.
At Genesis Lifestyle Medicine, we understand that weight loss is a deeply personal journey. Our team of professionals is here to help you explore new options, like FDA-approved weight loss injections, that could give you the extra support you need to shed unwanted pounds. In this article, we explore the most popular weight loss shots available and help you determine which one may be the best fit for your lifestyle.
Liraglutide (Saxenda)
Liraglutide (Saxenda) is a GLP-1 receptor agonist originally developed for managing diabetes but is now approved for weight loss. GLP-1 stands for glucagon-like peptide-1, a hormone produced in the gut that helps regulate blood sugar levels by increasing insulin secretion and reducing glucagon levels. When you take Saxenda, the GLP-1 hormone is activated, which helps control blood sugar levels and slows gastric emptying, making you feel fuller for longer.
This slower digestion process is one of the reasons why Saxenda helps with weight loss. By keeping you feeling satiated for extended periods, it helps reduce overall calorie intake. The increased fullness helps curb cravings and overeating, which contributes to weight loss over time. Saxenda is administered via daily injections, allowing for consistent dosage to regulate appetite and food intake effectively.
How effective is it?
In clinical trials, around 60% of adults using Saxenda for a year achieved a weight loss of 5% or more from their baseline body weight, roughly 12 pounds. About one-third of patients lost 10% or more of their body weight, while 6% saw a weight loss of 20% or more. While not a rapid fix, consistent use with a healthy lifestyle can provide significant results.
Semaglutide (Wegovy)
Semaglutide (Wegovy) is another GLP-1 receptor agonist, similar to Saxenda, but with a slightly different formulation. While both medications mimic GLP-1 in the body, Wegovy’s higher dose makes it more effective for weight loss. Semaglutide activates GLP-1 receptors in the brain and gastrointestinal tract to regulate appetite and food intake. It slows down the emptying of your stomach and signals to your brain that you are full, thereby decreasing hunger.
By slowing digestion, Wegovy helps regulate your appetite, making it easier to consume fewer calories without feeling deprived. This process also contributes to improvements in blood sugar regulation, further enhancing its efficacy for weight loss. Wegovy is administered once a week via an injection, making it a more convenient option than Saxenda’s daily shots.
How effective is it?
Wegovy has shown impressive results in clinical studies. On average, patients lost about 15% of their body weight, which is roughly 35 pounds, after 68 weeks of treatment. Additionally, 30% of participants lost 20% or more of their body weight, which can translate to around 46 pounds. This medication can provide dramatic results when combined with a balanced diet and lifestyle.
Tirzepatide (Zepbound)
Tirzepatide (Zepbound) is the newest weight loss medication on the market. What makes Zepbound unique is its dual mechanism of action—it activates both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors. GIP is another hormone involved in regulating insulin and glucose metabolism. By targeting both receptors, Zepbound effectively slows gastric emptying, reduces appetite, and enhances insulin sensitivity.
This dual action is why Zepbound has shown remarkable results in weight loss. The added benefit of GIP receptor activation is that Zepbound may have more dramatic weight loss effects than other medications in the GLP-1 class. It helps you feel full faster and for longer periods, making it easier to reduce calorie intake and lose weight.
How effective is it?
In clinical trials, Zepbound showed exceptional results. On average, patients lost 26% of their body weight over 88 weeks, which is approximately 58 pounds. A staggering 72% of participants lost 20% or more of their body weight. This makes Zepbound one of the most effective weight loss injections available. However, it still requires a commitment to diet and exercise.
Which weight loss shot is the best for me?
Choosing the best weight loss shot depends on several factors, including your health goals, lifestyle, and how your body responds to treatment. If you prefer a medication with a well-established track record, Saxenda might be a good choice, especially if you're okay with daily injections. If you're looking for more impactful results, Wegovy might be a better fit. However, if you're seeking the most significant weight loss results, Zepbound may be the right choice.
No matter which injection you choose, it’s important to remember that weight loss is a journey that involves consistent effort, including a balanced diet and regular physical activity. Schedule a consultation at Genesis Lifestyle Medicine, our team of experts is here to help guide you through the process and find the best weight loss treatment to support your individual goals.
