If you’re considering Wegovy for weight loss or already taking it, you might have concerns about potential side effects—especially those related to your heart. While Wegovy (semaglutide) has been shown to be effective for weight management and even beneficial for heart health in many patients, some people have reported experiencing heart palpitations or an increased heart rate while on the medication. So, is there a real link between Wegovy and heart palpitations?

At Genesis Lifestyle Medicine, we take your health seriously—from the inside out. Our expert providers specialize in personalized care, and that includes helping you take medications like Wegovy safely and effectively. Whether you’re starting your weight loss journey or managing side effects along the way, we’re here to support you.

How does Wegovy work?

Wegovy (semaglutide) is a medication approved for chronic weight management in people who are overweight or suffering from obesity, particularly if they also have weight-related conditions like high blood pressure or type 2 diabetes. It belongs to a class of drugs called GLP-1 receptor agonists, which were originally developed for diabetes treatment.

GLP-1 stands for glucagon-like peptide-1, a hormone your body naturally produces after eating. This hormone helps regulate your appetite, insulin production, and blood sugar levels. Wegovy mimics the action of GLP-1 by binding to the same receptors in your brain and pancreas.

Here’s how GLP-1 receptor agonists like Wegovy work:

• Reduce appetite: Wegovy works in the appetite centers of your brain, helping you feel full faster and stay full longer.
  
• Slow gastric emptying: Wegovy slows down how quickly food leaves your stomach, which helps reduce hunger and support more stable blood sugar levels.
  
• Improve insulin function: It makes your pancreas more responsive to blood sugar, helping your body manage glucose more effectively.

What are the common side effects of Wegovy?

As with any medication, Wegovy can cause side effects. Most are mild to moderate and tend to lessen over time as your body adjusts. Common side effects of Wegovy include:

• Nausea
• Vomiting
• Diarrhea
• Constipation
• Headache
• Fatigue
• Indigestion
• Dizziness

Does Wegovy cause heart palpitations?

Yes, Wegovy can potentially cause heart palpitations in some individuals, though this side effect is relatively uncommon. Clinical trials have shown that semaglutide may raise resting heart rate by a few beats per minute, and in sensitive individuals, that change could lead to noticeable palpitations or irregular rhythms. Let’s look at the possible reasons behind this reaction.

Increased sympathetic nervous system activity

GLP-1 receptor agonists like Wegovy may stimulate the sympathetic nervous system—the part of your body responsible for the "fight or flight" response. This stimulation can lead to an increase in heart rate and, in some cases, a fluttering or racing sensation in the chest.

Changes in blood sugar levels

As Wegovy helps your body regulate blood sugar more effectively, some may experience low blood sugar—especially if they’re also on diabetes medications. When blood sugar drops too low, your body releases adrenaline, leading to shakiness, sweating, and heart palpitations.

Electrolyte imbalances from nausea or vomiting

Frequent vomiting or diarrhea—common side effects of Wegovy, especially early on—can lead to electrolyte imbalances. A lack of potassium, magnesium, or calcium can trigger abnormal heart rhythms or palpitations.

Dehydration

Nausea and vomiting can also cause dehydration, which puts extra strain on your cardiovascular system. When your body lacks fluid, your heart may need to pump faster to maintain blood flow, potentially causing palpitations.

Individual sensitivity or pre-existing heart conditions

Some people are simply more sensitive to changes in heart rate, or they may have underlying heart conditions that make them more prone to noticing palpitations. If you’ve had arrhythmias or other cardiac issues in the past, it’s important to monitor your response to Wegovy closely.

Tips to manage heart health while on Wegovy

If you’re taking Wegovy and are concerned about your heart health, there are several proactive steps you can take to reduce your risk and stay safe.

• Monitor your heart rate regularly: Keep track of your resting heart rate—especially during the first few weeks of treatment or after a dosage increase. Wearable devices like fitness trackers or smartwatches can make this easy to do at home.
  
• Stay hydrated and replenish electrolytes: To prevent dehydration and electrolyte imbalance, drink plenty of water throughout the day and consider replenishing with an electrolyte drink if you experience vomiting, diarrhea, or excessive sweating.
  
• Avoid stimulants like caffeine and nicotine: Caffeine and nicotine can amplify heart rate changes, increasing the likelihood of palpitations. Try reducing your intake or avoiding these substances entirely while adjusting to Wegovy.
  
• Eat small, balanced meals: Large meals or long gaps between eating can affect blood sugar and trigger palpitations. Eating smaller, balanced meals throughout the day can help stabilize your system and support heart health.
  
• Communicate with your healthcare provider: If you feel your heart racing, skipping beats, or notice any irregularities, don’t ignore it. Your provider may recommend adjusting your dose, trying a different medication, or doing further testing to rule out other conditions.

Talk to Genesis Lifestyle Medicine about weight loss

Wegovy can be a powerful tool in your weight loss journey, but your heart health should never be compromised along the way. At Genesis Lifestyle Medicine, our experienced medical team monitors your progress closely and ensures any side effects—like heart palpitations—are addressed promptly and effectively.

If you're considering Wegovy or have concerns about side effects, schedule a consultation today. Let’s ensure your path to better health is safe and successful.