If you’ve recently started taking Wegovy for weight loss, you might be noticing some unexpected changes in your menstrual cycle. Whether your period is late, heavier, lighter, or even absent altogether, it’s natural to wonder if the medication is to blame. The short answer? Wegovy doesn’t directly affect your period, but it can lead to changes indirectly.

At Genesis Lifestyle Medicine, we understand that every part of your health journey matters — including your menstrual health. We’re here to help you understand how medications like Wegovy work, what they can impact, and how you can manage those effects.

How does Wegovy work?

Wegovy is a prescription weight loss medication that contains semaglutide, a compound that mimics a natural hormone in your body called GLP-1 (glucagon-like peptide-1). GLP-1 is released in your gut after you eat and helps regulate appetite and blood sugar.

When you take Wegovy, it acts like GLP-1 by:

• Slowing down digestion so food stays in your stomach longer, helping you feel fuller.
  
• Reducing hunger by interacting with the area of your brain that controls appetite.
  
• Improving blood sugar control by encouraging your pancreas to release more insulin and reducing another hormone called glucagon.

This combination leads to lower calorie intake, less frequent hunger, and steady weight loss over time. While this is a great benefit for your physical health, the hormonal changes associated with weight loss can sometimes affect your menstrual cycle.

Can Wegovy affect your period?

Wegovy doesn’t directly interfere with your period. It doesn’t contain hormones like estrogen or progesterone, and it doesn’t raise or lower your hCG levels (the hormone pregnancy tests detect). However, some users do report changes to their periods — from irregular cycles to missed periods. Let’s look at some indirect reasons Wegovy may impact your cycle.

Weight loss can lower estrogen levels

When you lose weight—especially rapidly—your body fat percentage decreases. Fat cells help produce estrogen, the hormone that plays a big role in your menstrual cycle. With less body fat, your estrogen levels may drop, which can lead to irregular, lighter, or missed periods.

Rapid weight loss may signal stress to the body

Losing a significant amount of weight quickly can send your body into a kind of “stress mode.” It might think you’re going through starvation, and in response, your body may temporarily shut down non-essential systems — including your reproductive system. This can lead to missed periods or even temporary amenorrhea (absence of menstruation).

Hormonal shifts may affect ovulation

Estrogen and progesterone are two key hormones involved in ovulation and menstruation. When your weight fluctuates, these hormones can become unbalanced, making it harder for your body to ovulate. If you don’t ovulate, your period may become irregular or stop altogether.

Weight loss may actually improve menstrual regularity

On the flip side, if you were previously overweight or obese, losing weight with Wegovy could help regulate your periods. Excess weight can disrupt hormones and lead to irregular cycles or conditions like PCOS (polycystic ovary syndrome). So, in some cases, Wegovy may actually bring your menstrual cycle into a more predictable rhythm over time.

Tips to manage your menstrual cycle on Wegovy

While some changes in your menstrual cycle may be temporary, there are steps you can take to support hormonal balance and cycle regularity while on Wegovy.

Track your cycle and symptoms

Start using a period tracker app or journal to monitor changes in your cycle. Track symptoms, flow intensity, mood changes, and timing. This data can help you spot patterns and provide helpful information for your healthcare provider.

Focus on a balanced, hormone-friendly diet

Fuel your body with a nutrient-dense diet that supports hormone production. Focus on:

• Healthy fats (avocados, nuts, seeds)
• Lean proteins
• Complex carbs (vegetables, whole grains)
• Plenty of hydration

Avoid extreme calorie restriction, processed foods, and added sugars—these can increase inflammation and disrupt hormonal balance.

Move your body regularly

Exercise can improve hormonal balance, reduce insulin resistance, and support healthy ovulation. Aim for moderate, consistent activity like walking, cycling, or yoga—but don’t overdo it, as excessive exercise can also lead to missed periods.

Manage your stress levels

Chronic stress can lead to elevated cortisol, which suppresses reproductive hormones. Incorporate stress-reduction techniques like meditation, deep breathing, journaling, or talking with a therapist. Your body and hormones will thank you.

Talk to a doctor if irregularities persist

If your periods become very irregular, stop entirely, or come with other symptoms (like excessive pain, bleeding, or hormonal side effects), consult a provider who can assess your hormone levels, evaluate any underlying conditions, and tailor your care plan accordingly.

Stay at a healthy weight

Both low and high body weight can impact your cycle. The goal isn’t extreme weight loss but reaching a weight that supports your overall health and hormonal balance. Your team at Genesis Lifestyle Medicine can help guide you toward a sustainable, healthy target.

Your wellness journey is personal—we're here to support you

At Genesis Lifestyle Medicine, we understand that your body is unique, and so is your response to medications like Wegovy. Whether you're experiencing period changes, managing weight loss, or navigating hormonal shifts, we help guide you with personalized, compassionate care.

If you have questions or concerns about how Wegovy is affecting your menstrual cycle, don’t hesitate to contact us. Our team of medical professionals, hormone specialists, and wellness experts is committed to helping you achieve optimal health—from the inside out.