If you’re considering Ozempic (semaglutide) for managing weight, diabetes, or other health concerns, you may wonder how it affects women. Does Ozempic affect women differently than men? The answer is yes, to some extent.

While Ozempic works the same way in men and women by regulating blood sugar and aiding weight loss, some women report specific side effects more frequently. These may include gastrointestinal discomfort, nausea, and changes in hormone levels. However, these side effects vary from person to person, and not every woman will experience them. In this article from Genesis Lifestyle Medicine, we will dive deeper into how Ozempic can affect women and explore the factors to consider.

How Ozempic works and its effects on the body

Ozempic is a GLP-1 (glucagon-like peptide-1) agonist primarily prescribed for Type 2 diabetes. It helps regulate blood sugar levels and, in many cases, reduces the risk of heart attacks or strokes in those with cardiovascular disease. Besides treating diabetes, healthcare providers also use Ozempic to help manage weight. It mimics the GLP-1 hormone, which helps lower appetite and slow digestion, leading to reduced calorie intake.

Common side effects of Ozempic in women

Although Ozempic can be beneficial for managing Type 2 diabetes and weight loss, women may experience certain side effects more commonly than men. These side effects are generally related to the gastrointestinal system and can include:

• Nausea and vomiting: Many women report feeling nauseous, especially when first starting the medication or increasing their dosage.
  
• Gastrointestinal discomfort: This can include abdominal pain, bloating, flatulence, and indigestion. Ozempic slows down digestion, which may irritate the stomach lining.
  
• Changes in appetite: While Ozempic is formulated to reduce hunger, some women experience a significant reduction in appetite, which may affect their overall eating habits.

Some women report feeling more fatigued or experiencing headaches in addition to digestive symptoms. Hair thinning is also possible in some cases, though this is less common.

How Ozempic affects hormone levels and fertility

Another key concern for women considering Ozempic is its potential impact on hormone levels, menstrual cycles, and fertility. Since Ozempic can lead to weight loss, this may indirectly affect hormones that regulate the menstrual cycle. Some women may experience changes in the regularity or intensity of their periods. For women trying to conceive, it’s important to discuss any concerns with your healthcare provider, as significant weight loss or hormonal imbalances could potentially influence fertility.

Ozempic during pregnancy

Ozempic is not recommended for use during pregnancy, as limited research has shown potential risks to a developing fetus. According to the FDA, animal studies have shown that GLP-1 agonists like Ozempic may affect fetal weight and growth. While the full impact on human pregnancies is not yet known, it’s best to discontinue Ozempic at least two months before trying to conceive. It’s essential to consult with your healthcare provider to explore safer alternatives for managing diabetes or weight during pregnancy.

Ozempic while breastfeeding

There is insufficient research on the safety of Ozempic during breastfeeding, and it’s unclear whether the medication passes into breast milk. Given the limited data, the medical community generally recommends alternative treatments, such as insulin or metformin, for breastfeeding mothers. Saxenda (liraglutide) has also been proposed as an alternative, though it hasn't been definitively approved for use during lactation either. If you’re nursing, discuss alternative diabetes and weight management options with your doctor.

How to manage the side effects of Ozempic

While Ozempic is generally well-tolerated, some women may experience long-term side effects. These can include persistent nausea, digestive discomfort, and potential gallbladder issues.

If you’re experiencing side effects from Ozempic, it’s important to manage them effectively to maintain your comfort and health. While side effects are common when starting the medication or adjusting your dosage, there are several strategies you can adopt to reduce discomfort and ensure a smooth treatment experience.

• Gradually increase the dose to help your body adjust more comfortably
• Stay hydrated, especially if experiencing diarrhea or vomiting
• Avoid greasy, fatty foods that may worsen nausea or gastrointestinal discomfort
• Opt for fiber-rich foods to support digestive health
• Eat smaller, more frequent meals to reduce stomach discomfort
• Take your medication at the same time each week to establish a routine
• Monitor your blood sugar levels regularly to avoid hypoglycemia
• Communicate any new or worsening symptoms to your healthcare provider
• Consider alternative treatments if side effects become intolerable
• Ensure regular check-ups to assess your progress and make necessary adjustments

Is Ozempic the right choice for you?

While Ozempic can be an effective treatment for weight loss and diabetes management, women may experience specific side effects that require attention. At Genesis Lifestyle Medicine, we recognize that each person’s health journey is unique, and we offer tailored solutions to help you achieve your wellness goals while minimizing risks. Contact us today to learn more about how Ozempic can fit into your personalized treatment plan.