You’ve started taking Semaglutide for weight loss and are excited about the potential benefits. Within a few weeks, you notice that your appetite has decreased, and the scale is finally moving in the right direction. But something feels off—you’re experiencing unexplained restlessness, an increase in anxious thoughts, or even full-blown anxiety attacks.

Semaglutide medications like Ozempic and Wegovy have become widely popular for their effectiveness in managing diabetes and supporting weight loss. However, as more people begin using them, reports of potential mental health side effects—including anxiety—are emerging. At Genesis Lifestyle Medicine, we prioritize a holistic approach to wellness, considering not only physical health but also mental well-being. If you’re taking or considering Semaglutide, it’s essential to understand how it might impact your mental health.

Can Semaglutide cause anxiety?

While Semaglutide has been primarily studied for its benefits in controlling blood sugar and weight, some users report experiencing increased anxiety. Research on the direct link between Semaglutide and anxiety is still evolving, but there are several possible explanations for why some people may feel more anxious while on this medication.

Semaglutide mimics GLP-1, a hormone that regulates appetite and blood sugar. However, GLP-1 receptors are also found in the brain, where they influence mood, stress response, and even neurotransmitter levels. Disruptions in these processes may contribute to increased feelings of anxiety. Additionally, the drug’s effects on digestion—such as slowed gastric emptying—can alter gut microbiome balance, which plays a crucial role in mental health.

Possible effects of Semaglutide on mental health:

• Increased anxiety and restlessness: Some people on Semaglutide experience a heightened sense of nervousness or restlessness. This may stem from changes in blood sugar levels, neurotransmitter activity, or the body’s adjustment to reduced calorie intake.
  
• Mood swings and emotional instability: Sudden shifts in mood can be another side effect of Semaglutide. You may feel fine one moment and irritable or overwhelmed the next. These fluctuations could be linked to changes in insulin regulation, which affects brain chemistry.
  
• Depression and low energy levels: While Semaglutide helps many people feel more in control of their eating habits, some report experiencing depression or low energy. This may be due to changes in dopamine and serotonin levels, which influence motivation and mood.
  
• Sleep disturbances: Some people taking Semaglutide notice changes in their sleep patterns, including trouble falling asleep, waking up frequently during the night, or feeling excessively tired during the day. Poor sleep quality can worsen anxiety and impact overall mental health.

Tips to manage anxiety while on Semaglutide

Monitor your symptoms and communicate with your provider

Keep track of any changes in your mood, anxiety levels, or sleep patterns. Writing in a journal or using a symptom tracker can help you identify patterns and discuss concerns with your provider. If anxiety becomes severe, your doctor may adjust your dosage.

Maintain balanced blood sugar levels

Low or fluctuating blood sugar levels can contribute to feelings of anxiety. Eating balanced meals with a mix of protein, healthy fats, and fiber-rich carbohydrates can help stabilize your blood sugar and reduce anxiety-related symptoms. Avoid skipping meals or drastically cutting calories, as this may worsen mood swings.

Prioritize gut health

Since Semaglutide affects digestion and the gut microbiome, supporting gut health is essential. Incorporating probiotic-rich foods like yogurt, kefir, and fermented vegetables can help maintain a healthy gut-brain connection. Staying hydrated and consuming fiber-rich foods can also support digestion and reduce gastrointestinal discomfort that may contribute to anxiety.

Practice stress-reducing techniques

Managing anxiety while on Semaglutide may require additional stress-management strategies. Techniques like deep breathing, meditation, yoga, or progressive muscle relaxation can help regulate your nervous system and keep anxiety in check.

Get enough sleep and maintain a consistent routine

Sleep disturbances can contribute to increased anxiety, so prioritize good sleep hygiene. Aim for 7-9 hours of quality sleep each night, establish a calming bedtime routine, and avoid screens before bed. If you struggle with sleep, speak with your provider about potential solutions.

Seek mental health support

If you find that anxiety is impacting your daily life, consider working with a mental health professional. A therapist can help you develop coping strategies, address underlying stressors, and ensure that your weight loss supports your physical and emotional well-being.

Semaglutide medications like Ozempic and Wegovy offer effective solutions for weight loss and diabetes management, but they may also come with unexpected mental health effects, including anxiety. While not everyone will experience these side effects, it’s essential to be aware of the potential risks and take proactive steps to manage them.

At Genesis Lifestyle Medicine, we believe in a comprehensive approach to wellness, supporting you at every step of your health journey. If you’re experiencing anxiety or other side effects while on Semaglutide, our team is here to provide guidance and personalized care.