It’s a regular workday, but you're doubled over with pain that feels anything but normal. Your abdomen throbs, your back aches, and it’s as if your body is working against you. For millions of people with endometriosis, this isn’t a one-off occurrence. These painful flare-ups can disrupt life, leaving you exhausted and searching for relief.

If this scenario sounds familiar, you might be wondering about solutions to ease the symptoms and prevent these episodes altogether. At Genesis Lifestyle Medicine, we understand how challenging managing endometriosis can be, and we’re here to help. Hormone therapy is one effective way to address the condition, potentially reducing or even preventing flare-ups. Let’s explore the options available and how they might work for you.

Hormonal contraceptives

Hormonal contraceptives, including birth control pills, patches, and vaginal rings, are among the most common treatments for endometriosis. These therapies regulate your menstrual cycle by controlling the hormones that trigger ovulation and the growth of endometriosis tissue. By reducing or eliminating ovulation, hormonal contraceptives decrease the monthly hormonal changes that can exacerbate endometriosis symptoms. This stabilization helps prevent the thickening and breakdown of tissue outside the uterus, reducing pain and inflammation.

Taking hormonal contraceptives continuously—without a break for menstruation—can offer even greater relief. This approach minimizes the number of periods you experience, which may reduce the likelihood of endometriosis flare-ups.

Progestin therapy

Progestin therapy is another effective hormonal option. Progestin is a lab-made version of progesterone, a hormone involved in the menstrual cycle and pregnancy. Available as pills, injections, implants, or intrauterine devices (IUDs), progestin can help manage endometriosis symptoms. Progestin limits the growth of endometriosis tissue by suppressing ovulation and thinning the lining of the uterus. This action reduces the likelihood of endometrial-like tissue outside the uterus thickening and causing inflammation.

For those seeking convenience, progestin-releasing IUDs, like Mirena or Skyla, provide years of relief. These devices not only prevent pregnancy but also create a localized effect in the uterus, reducing pain and potentially shrinking existing endometriosis tissue.

GnRH agonists and antagonists

Gonadotropin-releasing hormone (GnRH) therapies are powerful options for managing endometriosis flare-ups. These treatments work by creating an artificial menopause, lowering estrogen levels to a point where endometriosis tissue can no longer grow or spread. GnRH agonists and antagonists stop the production of estrogen, the hormone most responsible for fueling endometriosis growth. This shrinks existing lesions and prevents new ones from forming.

Since this therapy mimics menopause, you may experience side effects like hot flashes or bone thinning. However, combining GnRH therapies with low doses of estrogen or progestin can reduce these issues while maintaining their effectiveness.

Aromatase inhibitors

Aromatase inhibitors are a newer class of medications that work by blocking the production of estrogen in the body. Originally developed to treat breast cancer, these medications are now showing promise in managing endometriosis symptoms. Endometriosis tissue is highly sensitive to estrogen. By reducing its presence, aromatase inhibitors shrink existing tissue and prevent flare-ups. These medications are often combined with other hormonal therapies, such as progestin or GnRH treatments, to enhance their effectiveness.

Other possible ways to prevent endometriosis flare-ups

While hormone therapy is highly effective, you can take additional steps to manage your condition and improve your quality of life.

• Maintain an anti-inflammatory diet: Foods rich in omega-3 fatty acids, antioxidants, and fiber can help reduce inflammation. Add plenty of fruits, vegetables, whole grains, and fatty fish to your meals, and avoid inflammatory foods like processed meats and excessive sugar.
  
• Manage stress effectively: Stress doesn’t directly cause endometriosis flare-ups, but it can worsen your perception of pain and lead to hormonal imbalances. Practices like yoga, meditation, or regular exercise can help you keep stress in check.
  
• Get regular exercise: Moderate physical activity improves circulation, reduces inflammation, and boosts endorphins, which are natural painkillers. Aim for activities like walking, swimming, or cycling to stay active without overexertion.

Endometriosis doesn’t have to control your life. Hormone therapy offers a proven path to relief, whether through contraceptives, progestin, GnRH therapies, or aromatase inhibitors. Combined with lifestyle adjustments and expert guidance from Genesis Lifestyle Medicine, you can take steps to prevent painful flare-ups and reclaim your everyday comfort. Contact us today!