If you're using Ozempic for weight loss or diabetes management, you've likely heard about its impressive ability to stabilize blood sugar and curb appetite by slowing the digestive process. However, this benefit can sometimes come with a concerning side effect: gastroparesis or stomach paralysis. For some individuals, especially those with diabetes or obesity, Ozempic may slow digestion too much, leading to uncomfortable and potentially dangerous symptoms such as nausea, vomiting, and bloating.

At Genesis Lifestyle Medicine, we help you navigate your health journey while managing side effects like gastroparesis. Here are six essential tips for managing gastroparesis while on Ozempic to help you find relief and improve your quality of life.

What is gastroparesis?

Gastroparesis is when the stomach muscles cannot contract properly, preventing food from moving through the digestive system at an average pace. In a healthy digestive system, the stomach contracts and pushes food into the intestines shortly after a meal. When the stomach muscles are weakened or paralyzed, food can remain in the stomach for prolonged periods, leading to nausea, vomiting, bloating, and feeling full after eating only a small amount. This can cause serious complications, including malnutrition and abnormal blood sugar levels.

How does Ozempic cause gastroparesis?

Ozempic works by slowing down digestion. As a GLP-1 receptor agonist, Ozempic delays the movement of food from the stomach to the intestines to keep blood sugar levels stable and help users feel full for longer periods. While this slower digestion is beneficial for controlling appetite, it can sometimes slow the digestive process too much, leading to gastroparesis. In fact, up to 1 in 20 people on GLP-1 medications like Ozempic may develop some form of stomach paralysis.

How to manage gastroparesis while on Ozempic

1. Work closely with your healthcare provider

One of the most important steps when dealing with gastroparesis while on Ozempic is maintaining close communication with your healthcare provider. They can help monitor your symptoms, adjust your medication, and provide tailored advice. Be sure to keep your doctor informed about any changes in your digestive health, especially if you notice symptoms like nausea, bloating, or vomiting that persist for more than a month.

Your healthcare provider may adjust your dosage or recommend a switch to another medication if your symptoms become severe. For example, alternatives like liraglutide (Saxenda, Victoza) or even non-GLP-1 medications could be considered.

2. Make strategic changes to your diet

Diet plays a crucial role in managing gastroparesis, and small adjustments can make a big difference. Start by eating smaller, more frequent meals throughout the day instead of three large meals. This reduces the strain on your stomach and helps food pass more easily into your intestines. Additionally, focus on soft, well-cooked foods that are easier to digest, like mashed potatoes, pureed soups, and smoothies.

Avoid high-fat and high-fiber foods, as they can slow down digestion even further. Foods like fatty meats, fried items, and raw vegetables may worsen gastroparesis symptoms. Instead, opt for low-fat options and consider drinking liquids that contain glucose and electrolytes, such as low-fat broths or sports drinks, to maintain your energy levels. A balanced diet, rich in nutrients but easy on your stomach, can help mitigate the symptoms of gastroparesis.

3. Stay hydrated and manage blood sugar levels

Dehydration is a common issue for those dealing with gastroparesis, especially if you’re experiencing vomiting or diarrhea. Ensuring that you stay hydrated is essential. Drink plenty of fluids throughout the day, but do so in small amounts at regular intervals to avoid overwhelming your stomach. Water, clear broths, and herbal teas are excellent choices, but avoid carbonated beverages and alcohol, which can aggravate your symptoms.

In addition to staying hydrated, managing your blood sugar levels is critical, particularly if you have diabetes. High blood sugar can slow down your digestive system even more, exacerbating gastroparesis. Work with your healthcare provider to adjust your diabetes management plan, including insulin timing and dosage, to prevent further digestive issues.

4. Consider medication to assist with digestion

For individuals whose gastroparesis symptoms persist despite dietary changes, certain medications can help improve stomach motility and alleviate symptoms like nausea and vomiting. Your doctor may prescribe drugs like metoclopramide, which helps increase stomach contractions, or antiemetics, which can reduce nausea and prevent vomiting.

While these medications can be helpful, they are not without risks. It’s essential to follow your doctor's guidance carefully and report any side effects you experience. At Genesis Lifestyle Medicine, we are committed to providing holistic care, ensuring you receive the most appropriate treatments for your individual needs while minimizing unwanted effects.

5. Incorporate gentle physical activity after meals

Light physical activity after meals can help stimulate digestion and improve the passage of food through your stomach. Consider taking a gentle walk for 10 to 20 minutes after eating. Not only can this aid in digestion, but it also promotes overall health and helps manage blood sugar.

It’s important to avoid strenuous exercise or any physical activity that requires lying down immediately after meals, as this can exacerbate symptoms. Staying upright for at least two hours after eating can help keep food moving downward through your digestive tract.

6. Know when to seek emergency care

While gastroparesis symptoms can often be managed with diet, medication, and lifestyle changes, there are times when it’s essential to seek immediate medical attention. If you experience severe abdominal pain, are unable to keep food or liquids down, or show signs of dehydration (such as dizziness, dark urine, or extreme thirst), contact urgent care.

Additionally, if you notice blood in your vomit or stools or if your abdominal pain comes on suddenly and is intense, it’s critical to seek prompt medical attention.

Managing gastroparesis with care and support

Gastroparesis while on Ozempic can be challenging. However, by working closely with your healthcare provider, making strategic dietary changes, staying hydrated, and incorporating gentle physical activity, you can effectively manage your symptoms. Schedule a consultation at Genesis Lifestyle Medicine, we are dedicated to guiding you every step of the way, ensuring you have the tools and support to maintain your health and quality of life while on Ozempic.