Ozempic (Semaglutide) is an effective medication for managing Type 2 diabetes and aiding weight loss. However, it can sometimes cause heartburn, a common side effect that can be uncomfortable and disruptive. If you’ve started experiencing heartburn while on Ozempic, don’t worry. There are several strategies you can use to manage this side effect effectively. Here are five tips to help you stay comfortable and get the most out of your treatment.

1. Avoid foods and drinks that trigger heartburn

One of the most effective ways to manage heartburn is to avoid foods and drinks that can trigger it. Certain foods and beverages are known to relax the lower esophageal sphincter, allowing stomach acid to escape into the esophagus and causing that burning sensation. Greasy, fried, and spicy foods are notorious for triggering heartburn, as they can irritate the stomach lining and increase acid production. Chocolate, citrus fruits, and tomatoes can also increase acid secretion and relax the lower esophageal sphincter.

Generally speaking, you should avoid these foods and drinks:

• Greasy and fried foods
• Spicy foods
• Chocolate
• Citrus fruits and tomatoes
• Caffeinated drinks
• Alcohol
• Peppermint

Instead, opt for foods and drinks that are less likely to cause heartburn, including:

• Watermelon
• Cantaloupe
• Bananas
• Dates
• Chicken
• Turkey
• Salmon

2. Change your sleep position

Heartburn often worsens at night when you lie down because gravity no longer helps keep stomach acid down. Adjusting your sleep position can make a big difference in managing heartburn. Elevating your head and upper body helps to keep stomach acid in your stomach, preventing it from rising into your esophagus. You can also use a wedge pillow or raise the head of your bed by 6 to 10 inches to prevent stomach acid from rising.

Sleeping on your left side can also help. The esophagus enters the stomach on the right side, so when you sleep on your left side, the junction between the stomach and esophagus is higher, which helps keep acid in the stomach. Avoid sleeping on your back, as this position can make reflux worse by allowing acid to flow more easily into the esophagus. These adjustments can help keep stomach acid where it belongs and minimize nighttime heartburn.

These are some general tips for sleeping to reduce heartburn:

• Sleep with your head and upper body slightly elevated.
• Use a wedge pillow or raise the head of your bed by 6 to 10 inches.
• Sleep on your left side to keep the stomach acid below the esophagus.
• Avoid sleeping on your back, as this can make reflux worse.

3. Wear loose clothes

Tight clothing can put extra pressure on your stomach, forcing acid into your esophagus and triggering heartburn. By choosing loose-fitting clothes, especially around your waist, you can alleviate some of this pressure and reduce heartburn symptoms. Furthermore, comfortable, stretchy fabrics that don’t constrict your midsection can help keep you more comfortable throughout the day and prevent the onset of heartburn. This small change in your wardrobe can make a big difference in managing heartburn symptoms.

Here are some clothing tips to prevent the onset of heartburn:

• Opt for loose-fitting pants, skirts, and dresses.
• Avoid tight belts and waistbands.
• Choose comfortable, stretchy fabrics that don’t constrict your midsection.

4. Try an over-the-counter reflux medication

If lifestyle and dietary changes aren’t enough to manage your heartburn, over-the-counter (OTC) medications can provide relief. There are several types of OTC medications that can help alleviate heartburn symptoms, including:

• Antacids: Tums, Rolaids, Alka-Seltzer, and Mylanta. These work quickly to neutralize stomach acid and provide immediate relief, but their effects are short-lived.
• H2 blockers: Famotidine (Zantac 360, Pepcid AC) and cimetidine (Tagamet HB). These medications reduce the amount of acid your stomach produces. They take a few hours to start working but provide longer-lasting relief than antacids.

If you’re experiencing frequent or severe heartburn, you might want to keep both types of medication on hand—an antacid for immediate relief and an H2 blocker for longer-term management. Remember to follow the dosing instructions on the package and consult your healthcare provider if you have any concerns.

5. Talk with your healthcare provider

If you’ve tried lifestyle changes and OTC medications but are still experiencing heartburn, it’s time to talk with your healthcare provider. They can evaluate your symptoms and may prescribe stronger medications, such as proton pump inhibitors (PPIs), to help manage your heartburn. PPIs work by blocking the enzyme in the wall of the stomach that produces acid, reducing the amount of acid in the stomach.

Your healthcare provider can also review your other medications to ensure none are contributing to your symptoms. Some medications can relax the lower esophageal sphincter or irritate the stomach lining, making heartburn worse. Your provider may suggest alternatives if necessary. Don’t stop taking any medications without first consulting your healthcare provider. They can help you find the right combination of therapies to keep you comfortable and ensure you can continue benefiting from Ozempic’s therapeutic effects.

Heartburn doesn’t mean you have to give up on Ozempic

Experiencing heartburn on Ozempic doesn’t mean you have to stop using this medication. By implementing dietary changes, adjusting your sleep position, wearing loose clothing, using over-the-counter medications, and consulting your healthcare provider, you can manage heartburn effectively. Genesis Lifestyle Medicine is here to support you with personalized care and expert advice to help you stay comfortable while continuing your diabetes management and weight loss treatment with Ozempic.